Co-evolution of the branch site and SR proteins in eukaryotes
| dc.contributor.author | Plass, Mireya | en |
| dc.contributor.author | Agirre, Eneritz | en |
| dc.contributor.author | Reyes, Diana | en |
| dc.contributor.author | Camara, Francisco | en |
| dc.contributor.author | Eyras, Eduardo | en |
| dc.date.accessioned | 2025-06-16T17:35:58Z | |
| dc.date.available | 2025-06-16T17:35:58Z | |
| dc.date.issued | 2008 | en |
| dc.description.abstract | Serine-arginine-rich (SR) proteins are essential for splicing in metazoans but are absent in yeast. By contrast, many fungi have SIR protein homologs with variable arginine-rich regions analogous to the arginine-serine-rich (RS) domain in metazoans. The density of RS repeats in these regions correlates with the conservation of the branch site signal, providing evidence for an ancestral origin of SR proteins and indicating that the SIR proteins and the branch site co-evolved. | en |
| dc.description.sponsorship | M.P. is Supported by a grant from Instituto de Salud Carlos III, E.A. is supported by the project EURASNET from the European Commission and E.E. is supported by ICREA. | en |
| dc.description.status | Peer-reviewed | en |
| dc.format.extent | 5 | en |
| dc.identifier.other | WOS:000261712100003 | en |
| dc.identifier.other | PubMed:18992956 | en |
| dc.identifier.other | Scopus:56349150399 | en |
| dc.identifier.other | ORCID:/0000-0003-0793-6218/work/162948941 | en |
| dc.identifier.uri | https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=anu_research_portal_plus2&SrcAuth=WosAPI&KeyUT=WOS:000261712100003&DestLinkType=FullRecord&DestApp=WOS_CPL | en |
| dc.identifier.uri | https://hdl.handle.net/1885/733763690 | |
| dc.language.iso | en | en |
| dc.source | Trends in Genetics | en |
| dc.subject | Pre-messenger-rna | en |
| dc.subject | Splicing enhancers | en |
| dc.subject | Intron | en |
| dc.subject | Yeast | en |
| dc.subject | Evolution | en |
| dc.subject | Contact | en |
| dc.subject | Signals | en |
| dc.subject | Domain | en |
| dc.subject | Snrna | en |
| dc.title | Co-evolution of the branch site and SR proteins in eukaryotes | en |
| dc.type | Journal article | en |
| local.bibliographicCitation.lastpage | 594 | en |
| local.bibliographicCitation.startpage | 590 | en |
| local.contributor.affiliation | Plass, Mireya; Pompeu Fabra University | en |
| local.contributor.affiliation | Agirre, Eneritz; Pompeu Fabra University | en |
| local.contributor.affiliation | Reyes, Diana; Pompeu Fabra University | en |
| local.contributor.affiliation | Camara, Francisco; Pompeu Fabra University | en |
| local.contributor.affiliation | Eyras, Eduardo; Pompeu Fabra University | en |
| local.identifier.citationvolume | 24 | en |
| local.identifier.doi | 10.1016/j.tig.2008.10.004 | en |
| local.identifier.pure | 8b4a1c41-b454-4d53-8c87-dd2891227675 | en |
| local.type.status | Published | en |